Ishan Patro

Prof. Ishan Kumar Patro


Professor I.K. Patro holds M.Phil. and Ph.D. degree of Kurukshetra University, Kurukshetra. Had his Post-Doctoral at MRC Neurochemical Pathology Unit, Newcastle upon Tyne, UK, and Dept. of Anatomy, University of Cologne, Germany. He is now the Vice Chancellor of Ravenshaw University, Cuttack and Professor of Zoology/ Neuroscience at Jiwaji University, Gwalior with 30 years of teaching and 38 years of research experience.

He is a Fellow of the National Academy of Sciences (India), Indian Academy of Neurosciences and Collegium Internationale Neuropsychopharmalogicum.

He has several awards and honours to his credit including:

  1. A.V. Tilak Award of the Association of Gerontology (India) for the best research paper- 1988
  2. Defence Research and Establishment Award (Best Paper Award for Biological Sciences) 2010
  3. K.T. Shetty Memorial Oration of the Indian Academy of Neurosciences, 2012.
  4. Department of Biotechnology Incentive Awards for Publication- 2014 to Biotechnology Information Facility, Jiwaji University, Gwalior for getting the 3rd position in the category of BIF (Universities) for publication of papers in the journals of high repute in the year 2013. I am the Coordinator of the Facility.
  5. Late Prof. R.K Shrivastava Memorial Oration, Indian Science Congress Association (Sagar Chapter), 2017.
  6. B.K. Bachhawat Life-Time Achievement Award of Indian Academy of Neurosciences in the year 2018.

He has successfully completed 15 major research projects, guided 26 successful Ph.D. theses, published 85 papers in National and International journals, organized 23 conferences/ symposia/ workshops in biosciences and neuroscience.

Professor Patro has made significant contribution to glial neurobiology with special reference to the role of microglia and astrocytes in neurodegeneration and the perpetuating effect of glia on the health of the neurons and vice versa. Proposed immunosuppression as one of the mechanisms of neuroprotection. His group was first to report presence of microglia in dorsal root ganglia, phenotypically similar to those in the CNS with distinctive pathophysiological role in peripheral nerve injury.

His group is now very actively engaged in deciphering the impact of Maternal protein malnutrition (PMN) or perinatal exposure to Poly I:C (mimicking viral infection), lipopolysaccharide (mimicking bacterial infection) or deltamethrin that delayed formation and migration of granule cells, alteration in the level of several neuroregulatory proteins; impaired maturation, functional development of neurons, motor coordination and behavior. Combo exposures have multifold impact. They noted Spirulina as an economically viable supplement for PMN; Minocycline as an effective anti-inflammatory drug that rendered protection including better cognitive and behavioural abilities in addition to lowering of anxiety in the perinatally challenged. These studies suggest that either of the challenges present potential threat for later life neurological disorders.

He was rightly chosen as the Project Coordinator of the DBT National Initiative on Glial Cell Research in Health and Disease, with CCMB, CDRI, JNU, JU, NBRC and NIMHANS as participating Institutes.

His outstanding contribution to Human Resource Development in Neuroscience (M.Sc. and Ph.D. in Neuroscience since 2001) by establishment of India’s 1st UTD of Neuroscience at Jiwaji University, Gwalior deserves a special mention.


Citations/H-index:


Citations h-index i-10 index Research Gate Score
1186 22 35 32.37

Personal Information:


Prof. Ishan Kumar Patro

Ravenshaw University, Cuttack 753 003, Odisha
Phone: +91-6712200160 Mob: +91-9425110063
ishanpatro@gmail.com

Professor (On lien)
School of Studies in Zoology/ Neuroscience
Jiwaji University, Gwalior 474 011, India

Education Qualification


1986

PhD

Kurukshetra University, Kurukshetra
1982

M.Phil.

Kurukshetra University, Kurukshetra
1981

M.Sc.

Kurukshetra University, Kurukshetra
1978

B.Sc. (H)

Utkal University, Bhubaneswar

Honours and Awards:


HONOURS
  1. Fellow of the National Academy of Sciences, India (FNASc.)
  2. Fellow of the Collegium Internationale Neuro-Psychopharmacologicum (FCINP)
  3. Fellow of the Indian Academy of Neurosciences (FIAN)

AWARDS

  1. K.T. Shetty Memorial Oration of the Indian Academy of Neurosciences, 2012.
  2. Defence Research and Establishment Award (Best Paper Award for Biological Sciences) 2010
  3. A.V. Tilak Award of the Association of Gerontology (India) for the best research paper- 1988
  4. Department of Biotechnology Incentive Awards for Publication- 2014 to Biotechnology Information Facility, Jiwaji University, Gwalior for getting the 3rd position in the category of BIF (Universities) for publication of papers in the journals of high repute in the year 2013. I am the Coordinator of the Facility.
  5. Late Prof. R.K Shrivastava Memorial Oration, Indian Science Congress Association (Sagar Chapter), 2017
  6. B.K. Bachhawat Life-Time Achievement Award of Indian Academy of Neurosciences in the year 2018.

AWARDS TO DR. PATRO’S STUDENTS/ CO-INVESTIGATOR WHERE HE IS AN AUTHOR

  1. Dr. Nisha Patro: ‘Jyotsanamayee Raghunath Bhattacharya Prize’ for Best Paper published in 2009-10 by the Indian Academy of Neurosciences.
  2. Dr. Kapil Saxena: ‘Professor S. S. Parmar Research Foundation Award’ for best poster presentation at 22nd Annual Conference of Indian Academy of Neurosciences at Hyderabad Central University, Hyderabad (6th – 8th May 2004).
  3. Mr. Amit: ‘Professor S. S. Parmar Research Foundation Award’ for best poster presentation in International Conference on Recent Advances in Neuroscience and 27th Annual Meeting of Indian Academy of Neuroscience, Jaipur (18th -20th Dec 2009).
  4. Mr. Rakesh Kumar Banote: Best Oral presentation in National Conference on Herbal Medicine held at Bharthiyar University, Coimbatore (8-9th Sept 2010).
  5. Miss Arpita Sharma: Organiser’s award for Best Poster presentation in the 5th Congress of FAONS and 28th Annual Meeting of the Indian Academy of Neurosciences (IAN) held at IITR, Lucknow (25th -28th Nov 2010).
  6. Mrs. Surya Tripathi: ‘Best Poster presentation in FAONS Satellite Symposium on Glial Cells in Health and Disease’ held at School of Studies in Neuroscience, Jiwaji University, Gwalior (30th Nov -1st Dec 2010)
  7. Miss Arpita Sharma: ‘Best Poster presentation in 98th Indian Science Congress’ held at SRM University, Chennai (3rd -7th Jan 2011).
  8. Mr. Naik Aijaz ‘Best Paper for Poster Award from Indian Society of Cell Biology’ at 40thAll India Cell Biology Conference, Gwalior (17th -19th Nov 2016)
  9. Ms. Shrstha Sinha ‘Swarana Jayanti Puraskar for Best poster paper presentation from National Academy of Sciences India’ at 86thAnnual Session of Academy, Dehradun (2nd- 4thDec2016)
  10. Dr. Arpita Sharma ‘Jyotsanamayee Raghunath Bhattacharya Prize’for Best Paper published in 2016 by the Indian Academy of Neurosciences.
  11. Ms. Shrstha Sinha ‘Swarana Jayanti Puraskarfor Best oral paper presentation from National Academy of Sciences India’ at 87thAnnual Session of Academy, Pune (8th – 10th Dec 2017)

Research Supervision


Ph.D. Awarded=26; Working = 08;
M.Phil. Awarded = 06
AWARDED
Year Name of the Student Title of the Thesis
1996 Dr. Suresh Kumar Bhardwaj Influence of citiolone on age-related changes in mouse spinal cord and spinal ganglia
1996 Dr.Praveena Singhal Formation and removal of lipofuscin and its role in neuron loss in brainstem of ageing mice
1997 Dr.Munmun Chattopadhyay Effect of flunarizine on ageing and injured neurons
2006 Dr. Manisha Bajpai Studies of neurodegenerative changes following facial nerve transection
2006 Dr.Vandana Shrivastava Influence of flunarizine on pyrethroids induced developmental neurotoxicity
2008 Dr. Kapil Saxena Studies on the impact of FK506 on central glial response following peripheral nerve injury
2009 Dr. Sarika Kushwah Age related changes in astrocytes and microglia in the hippocampus and striate cortex
2009 Dr.AnchalGusain Studies on the potential role of calcineurin in cerebral ischemia/reperfusion injury
2010 Dr. Meghna Saxena Studies on influence of deltamethrin on glial responses during postnatal development of rat cerebellar cortex
2010 Dr. Pawan Kumar Therapeutic properties of Spirulina plantesis in collagen induced arthritis (CIA) in rats
2011 Dr. Mohsin Khan Therapeutic and prophylactic potential of certain antiviral compounds and recombinant vaccine candidates against chikungunya virus
2011 Dr. Gunjan Saxena Role of cholinergic system and mitochondria in caspase mediated apoptotic cell death in the experimental models of dementia
2012 Dr. Biswajit Mishra Design, synthesis and evaluation of peptide based antimicrobial compounds therapeutics against multidrug resistant strains
2012 Dr. Rekha Dhanwani Studies on basic patho-biology of chikungunya virus: Implecations of oxidative stress and related pathways in chikungunya pathogenesis
2013 Dr. Surya Tripathi Astroglia and microglial alteration in human brain disorders
2013 Dr. Amit Studies on the influence of neuroinflammation on neurodegeneration and neuroregeneration in a rat model of viral encephalitis
2013 Dr. P. Vijayabhaskar Deltamethrin developmental neurotoxicity in cerebral cortex
2013 Dr. S. Swarnkar Cellular and molecular studies on the rotenone induced neurotoxicity
2014 Dr.Kamendra Kumar Influence of maternal exposure to Deltamethrin during gestation on postnatal development rat cerebellum
2014 Dr. Arpita Sharma Influence of Minocycline on bacterial endotoxin lipopolysaccharide induced neuroinflammation associated cerebral degeneration
2014 Dr. Shashi Sharma Molecular detection and characterization of novel swine flu virus
2014 Miss. Divyasha Saxena Molecular detection and characterization of west Nile virus
2014 Mrs. Raj Priya Studies on neuropathogenesis and hostpathogen interaction of novel ECSA chikungunya virus genotypes with and without A226V mutation
2014 Mr. Shashank Tiwari Aging changes in glia and its impact on neuroprotection following peripheral nerve injury
2015 Miss Aarti Nagayach Glial changes in STZ induced diabetic rat brain/td>
- Mr. AIjaz Naik Studies on the impact of intra-generational protein malnutrition on gliogenesis and cognitive abilities in rats
Working
Name of the Student Title of the Thesis
Mrs. Kavita Singh Impact of early life bacterial (LPS) infection on developing and aging brain
Mr. Brijendra Singh Viral infection and glial response in rat brain
Ms. Shrstha Sinha* Genesis and recruitment of microglia in developing rat brain
Ms. Archana Sahu* In silico drug design for neurodegenerative disorders
Ms. Tiyasha Sarkar* Efficacy of Minocycline in a 3-hit model of schizophrenia
Mr. Sayed Mujtaba* Studies on impact of protein malnutrition and deltamthrine on cerebellar development
Ms. Urmila* Protein malnutrition and bacterial infection: Impact on the peri-neuronal net in rat brain
Mrs. Neha Sharma* Glial activation following environmental stress in Zebrafish
*= Final RDC approval awaited. They have qualified the Ph.D. entrance test of Jiwaji University

Professional Bodies


Service Career


Fellowships
Institution Position Period (From- To)
Kurukshetra University Junior Research Fellow (ICMR) 17.7.81- 20.3.84
Kurukshetra University Senior Research Fellow (ICMR) 21.3.84- 4.5.85
Kurukshetra University Research Associate (ICMR) 5.5.85- 31.12.86
Kurukshetra University Research Associate (UGC) 4.2.87- 4.12.87
Kurukshetra University Principal Investigator (DST/YS) 5.12.87- 2.1.89

Service as a Faculty
Institution Position Period (From- To)
Jiwaji University Lecturer 3.1.89- 26.7.98
Jiwaji University Reader 27.7.98- 26.7.06
Jiwaji University Professor 27.07.06- Cont
DST/YS= Department of Science & Technology Young Scientist Project;
ICMR= Indian Council of Medical Research; UGC= University Grants Commission
Teaching experience:28 years
Research Experience:36 years

Research Project


Total funds mobilized since 1989= Rs. 809.943 Lakhs
Title of Project Funding Agency Duration
Role of Neuroinflammation in brain aging and frailty Indian Council of Medical Research, Govt. of India, New Delhi 2014-2017
DBT-HRD Support Neuroscience Department of Biotechnology, New Delhi Since 2004
DBT- Bioinformatics Facility Department of Biotechnology, New Delhi Since 2006
Influence of certain geroprotectors on neuronal ageing in environ-mentally stressed and ageing albino rats Department of Science and Technology, New Delhi 1989-90
Experimental manipulation of longevity, lipofuscin formation and neuron loss in mouse brain Department of Science and Technology, New Delhi 21.10.1995
Studies on role of microglial activation in neuronal apoptosis Department of Biotechnology, New Delhi 31.3.2004
Studies on immunophilin ligands as novel modulators of glial activity and mediators of neuroprotection Department of Science and Technology, New Delhi 30.6.2006
Role of microglia in adult neurogenesis Department of Biotechnology, New Delhi June 2006, 4yrs.
Aging of microglia (Principal Investigator: I.K. Patro) Indian Council of Medical Research, Govt. of India, New Delhi 2007, 3 Years
Phenotypic alterations in astroglia and microglia in the brain- in response to tuberculous pathology in association with HIV/AIDS Department of Biotechnology, Govt. of India, New Delhi 2008-2009
Influence of early neurotoxic exposure on structural and cognitive aspects of cerebellum at adulthood and senility (PI: Dr. Nisha Patro) Department of Science & Technology, Govt. of India, New Delhi 2009-2012
Impact of maternal exposure to deltamethrin during gestation on cerebellar organization and cognitive development of the new born Indian Council of Medical Research, Govt. of India, New Delhi 2011-2014
Neuroimmunological and cognitive implications of perinatal bacterial (Lippoploysaccharide) infection during aging Department of Biotechnology, Govt. of India, New Delhi 2012- 2016
Perinatal viral infection neuroimmunological, molecular and cognitive consequences during development adulthood and senility in mice Department of Biotechnology, Govt. of India, New Delhi 2012- 2015
Impact of maternal protein malnutrition on the genesis, differentiation and maturation of astrocytes and oligodendrocytes (National initiative on glial cell research in health and disease) Department of Biotechnology, Govt. of India, New Delhi 2012- 2016

Publications


Papers published in peer-reviewed journals
Sinha, Shrstha, Patro, Nisha, Patro, I.K. (2018) Maternal protein malnutrition: Current and future perspectives of spirulina supplementation in neuroprotection. Front. Neurosci., DOI: doi.org/10.3389/fnins.2018.00966
Baghel, M.S., Singh, B., Dhuriya, Y.K., Shukla, R.K., Patro, N., Khanna, V.K., Patro, I.K. and Thakur, M.K. (2018) Postnatal exposure to poly (I:C) impairs learning and memory through changes in synaptic plasticity gene expression in developing rat brain. Neurobiol. Learn. Mem., 155: 379-389. (Impact Factor: 3.525)
Patro, N., Sinha, S., Singh, K., Chaudhary, J., and Patro, I.K. (2018) Enhanced adult neural stem cell population following bacterial infection during early postnatal life. Proc. Natl. Acad. Sci. India, Sect. B Biol. Sci., Doi: 10.1007/s40011-018-1028-3.
Patro, N., Hall R., Patro, I and Morris, C. M. (2018) The Contribution of Aluminium to Alzheimer’s disease: A Neuropathological Investigation of Renal Dialysis Cases. J Neurosci.Neurosurg. 1.4 1; DOI: 10.31021/jnn.20181118.
Patro, Nisha, Naik, A.A. and Patro, I.K. (2018) Developmental Changes in Oligodendrocyte Genesis, Myelination, and Associated Behavioral Dysfunction in a Rat Model of Intra-generational Protein Malnutrition. Mol. Neurobiol.: doi: 10.1007/s12035-018-1065-1. (Impact Factor: 6.19)
Kushwaha, S. S., Patro N., Patro, I.K. (2018)A sequential study of age-related lipofuscin accumulation in hippocampus and striate cortex of rat. Ann. Neurosci.DOI: 10.1159/000490908
Naik, A.A., Patro, Nisha, Seth, P. and Patro, I.K. (2017) Intra-generational protein malnutrition impairs temporal astrogenesis in rat brain. Biology Open: doi: 10.1242/bio.023432(Impact Factor: 2.5, Cited by 2)
Singh, Kavita, Patro, Nisha, Pradeepa, M. and Patro, I. (2017) Neonatal Lipopolysaccharide Infection Causes Demyelination and Behavioral Deficits in Adult and Senile Rat Brain. Ann. Neurosci.24:146–154.
Sharma, Arpita, Patro, Nisha and Patro, I.K. (2016) Lipopolysaccharide induced apoptosis of astrocytes: therapeutic intervention by minocycline. Cell. Mol. Neurobiol. 36:577–592. DOI 10.1007/s10571-015-0238-y (Impact Factor: 2.506, Cited by 7)
Naik, A.A., Patro, I.K. and Patro, Nisha (2015) Slow Physical Growth, Delayed Reflex Ontogeny, and Permanent Behavioral as Well as Cognitive Impairments in Rats Following Intra-generational Protein Malnutrition. Front. Neurosci. 9:446. doi: 10.3389/fnins.2015.00446 (Impact Factor: 3.7, Cited by 8)
Patro N., Naik, A. and Patro I.K. (2015) Differential temporal expression of S100b in developing rat brain. Front. Cell. Neurosci. 9:87. doi: 10.3389/fncel.2015.00087. (Impact Factor- 4.2, Cited by 10)
Kaur, H., Patro, I., Tikoo, K. and Sandhir, R. (2015) Curcumin attenuates inflammatory response and cognitive deficits in experimental model of chronic epilepsy. Neurochem Internat. 89:, 40-50. (Impact Factor- 3.385, Cited by 32)
1Nagayach, A, Patro, Nisha and Patro, Ishan (2015) Microglia in physiology and pathology of brain. Proc. Natl. Acad. Sci., India, Sect. B. DOI 10.1007/s40011-015-0585-y.(Cited by 1)
Nagayach, Aarti, Patro, Nisha and Patro, I. (2014) Experimentally induced diabetes causes glial activation, glutamate toxicity and cellular damage leading to changes in motor function. Front. Cell. Neurosci.Doi: 10.3389/fncel.2014.00355. (Impact Factor- 4.2, Cited by 27)
Tripathy, Surya, Patro, I., Mahadevan, A., Patro, Nisha, Philip, M. and Shankar, S.K. (2014) Astroglial and microglial alterations in tuberculous and cryptococcal meningitis and its relation to HIV co-infection- A morphometric study on human brain. J. Infect. Dev. Ctries. 8(11):1421-1443. (Impact Factor- 1.2, Cited by 6)
Priya, Raj, Patro, I.K. and Parida, M.M. (2014) TLR3 mediated immune response in mice brain following infection Chikungunya virus. Virus Res.189:194-205. (Impact Factor- 2.745, Cited by 20)
Priya, Raj, Dhanwani, R., Patro, I.K., Rao, P.V. and Parida, M.M. (2013) Differential regulation of TLR mediated innate immune response of mouse neuronal cells following infection with novel ECSA genotype of Chikungunya virus with and without E1:A226V mutation. Infect. Genet. Evol., 20: 396- 406. (Impact Factor- 2.768, Cited by 13)
Saxena D, Kumar JS, Parida M, Sivakumar RR, Patro IK. (2013) Development and evaluation of NS1 specific monoclonal antibody based antigen capture ELISA and its implications in clinical diagnosis of West Nile virus infection.J ClinVirol, 58(3):528-34. (Impact Factor- 3.287, Cited by 9)
Patro, N., Kumar, K. and Patro, I. (2013) Quick Golgi method: modified for high clarity and better neuronal anatomy. Indian J. Exp. Biol., 51 (9): 685-693. (Impact Factor- 1.295, Cited by 6)
Patro, Nisha, Singh, Kavita and Patro, I. (2013) Differential microglial and astrocytic response to bacterial and viral infection in the developing hippocampus of neonatal rats. Indian J. Exp. Biol., 51(8): 606-614. (Impact Factor- 1.295, Cited by 7)
Kumar, K., Patro, Nisha and Patro,I. (2013) Impaired Structural and Functional Development of Cerebellum Following Gestational Exposure of Deltamethrin in Rats: Role of Reelin. Cell. Mol. Neurobiol.,33(5):731-46(Impact Factor: 2.506, Cited by 20)
Sharma, Shashi, Joshi, G., Dash, P.K., Thomas, M., Athmaram, T.N., Kumar, J.S., Desai, A., Ravi, A., Patro, I.K., Rao and P.V., Parida, M.M. (2013) Molecular epidemiology and complete genome characterization of H1N1pdm virus from India. PLOS ONE,8(2): e56364. doi:10.1371/journal.pone.0056364. (Impact Factor – 4.4, Cited by 23)
Mishra, B, Leishangthem, G.D., Gill, K., Singh, A.K., Das, S., Singh, K., Xess, I., Dinda, A., Kapil, A., Patro, I.K. and Dey, Sharmistha (2013) A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida. Biochimica et Biophysica Acta, 1828 (2013) 677–686. (Impact Factor – 4.66, Cited by 40)
Swarnkar, S., Goswami, P., Kamat, P.K., Patro, I.K., Singh, Sarika and Nath, C. (2013) Rotenone induced neurotoxicity in rat brain areas: A study on neuronal and neuronal supportiveCells. Neuroscience, 230,172–183. (Impact Factor – 3.458, Cited by 18)
Swarnkar, Supriya, Singh, S., Goswami, P., Mathur, R., Patro, I.K. and Nath, C. (2012) Astrocyte activation: A key step in rotenoneinduced cytotoxicity and DNA damage. Neurochem. Res., 37(10):2178-89 (Impact Factor: 2.24, Cited by 27)
Swarnkar, Supriya, Goswami, P., Kamat, P.K., Gupta, S., Patro, I.K., Singh, S. and Nath, C. (2012) Rotenone-induced apoptosis and role of calcium: a study on Neuro-2a cells. Arch Toxicol., 86(9):1387-97. (Impact Factor: 4.041, Cited by 36)
Dhanwani, Rekha, Khan, M., Bhaskar, A.S.B., Singh, Rajpriya, Patro, Ishan, Rao, P.V.L. and Parida, M. (2012) Characterization of Chikugunya virus infection in human neuroblastoma SH-SY5Y cells: Role of apoptosis in neuronal cell death. Virus Res., 163: 417- 686. (Impact Factor: 2.905, Cited by 23)
Patro, N., Sharma, Arpita, Kariaya, K. and Patro I. (2011) Spirulina platensis protects neurons via suppression of glial activation and peripheral sensitization leading to restoration of motor function in collagen-induced arthritic rats. Indian J. Exp. Biol., 49:739-748. (Impact Factor- 1.295, Cited by 13)
Saxena, Gunjan, Patro, I.K. and Nath, C. (2011) ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor Behav. Brain Res., 224(1): 50-57. (Impact Factor: 3.393, Cited by 42)
Swarankar, Supriya, Singh, Sarika, Sharma, S., Mathur, R, Patro, I.K. and Nath, C. (2011) Rotenone induced neurotoxicity in rat brain areas: A histopathological study. Neuroscience Letters, 495:178-182. (Impact Factor: 2.055, Cited by 27)
Khan, M., Dhanwani, R., Patro, I.K., Rao, P.V.L. and Parida, M.M. (2011) Cellular IMPDH enzyme activity is a potential target for the inhibition of Chikungunya virus replication and virus induced apoptosis in cultured mammalian cells. Antiviral Res., 89: 1-8. (Impact Factor: 4.439, Cited by 68)
Khan Z., Khan, N., Tiwari, R.P., Patro, I.K., Prasd, G.B.K.S. and Bisen, P.S. (2010) Down-regulation of surviving by oxaliplatin diminishes radioresistance of head and nech squamous carcinoma cells. Radiother. Oncol., 96: 267-273. (Impact Factor: 4.831, Cited by 56)
Swarnkar, S., Singh, S., Mathur, R., Patro, I.K. and Nath, C. (2010) A study to correlate rotenone induced biochemical changes and cerebral damage in brain areas with neuromuscular coordination in rats. Toxicology, 272: 17–22. (Impact Factor: 3.641, Cited by 39)
Mishra, B., Srivastava V.K., Chaudhry, R., Somvanshi, R.K., Singh, A.K., Gill, K., Somvanshi, R., Patro, I.K. and Dey, S. (2010) SD-8, a novel therapeutic agent active against multidrug-resistant Gram positive cocci. Amino Acids, 39: 1493-1505. (Impact Factor: 4.106, Cited by 8)
Patro, Nisha, Nagayach, Aarti andPatro, I.K. (2010)Iba1 expressing microglia in the dorsal root ganglia become activated following peripheral nerve injury in rats. IndianJ. Exp. Biol.,48: 110-116. (Impact Factor: 1.295, Cited by 31)
Patro, I.K., Amit, Shrivastava, M., Bhumika, S. and Patro N. (2010) Poly I:C induced microglial activation impairs motor activity in adult rats. IndianJ. Exp. Biol.,48: 104-109. (Impact Factor- 1.295, Cited by 14)
Patro, Nisha, Kushwaha, S. and Patro, I.K. (2010) Aging of microglia: Does it influence neuroprotection. Proc. Nat. Acad. Sci. India, Sect. B, 80(1): 14-23. (Cited by 1)
Shrivastava, Meghna, Patro, Nisha, Kumar, K. and Patro, I.K (2009) Changes in pain sensitivity with age, differ in male and female Wistar rats, Rattus norvegicus (Berkenhout). Proc. Nat. Acad. Sci. India, Sect. B, 79(III): 235-239.
Kumar, N., Singh, S., Patro, Nisha and Patro, I.K. (2009) Evaluation of protective efficacy of Spirulina platensis against collagen induced arthritis in rats. Inflammopharmacology, 17(3): 181-190. (Cited by 33)
Patro, Nisha, Shrivastava, Meghna, Tripathi, Surya and Patro, I.K. (2009) S100βupregulation: A possible mechanism of deltamethrin toxicityand motor coordination deficits. Neurotoxicol. Teratol, 31:169-176. (Impact Factor: 3.274, Cited by 30)
Patro, I.K., Saxena, K., Tiwari, S. and Patro, N. (2008) FK-506 helps motor coordination recovery following sciatic nerve transaction in the young but not in the senile rats. Int. J. Neuroprotec. Neuroregen.,4(2):145-150.(Cited by 6)
Saxena, K., Patro, N. and Patro, I.K. (2007) FK506 protects neurons following peripheral nerve injury via immunosuppression. Cell. Mol. Neurobiol.,27:1049-1057. (Impact Factor: 2.423, Cited by 22)
Patro, N. and Patro, I.K. (2005) Effects of deltamethrin on granule cell migration during post-natal development of rat cerebellum. IndianJ. Exp. Biol., 43: 158-162. (Impact Factor- 1.295, Cited by 13)
Verma, D., Ray, S.B., Patro, I.K. and Wadhwa, S. (2005) Enhanced analgesic effect of morphine-nimidopine combination after intraspinal administration as compared to systemic administration in mice. J. Biosci., 30: 101-107. (Impact Factor: 1.888, Cited by 6)
Vimal, S., Sissodia, S.S., Meena, P., Barber, S., Shukla, S., Saxena, A., Patro, Nisha, Patro, I.K. and Bhatnagar, M. (2005) Antioxidant effects of Asparagus racemosus wild and WithaniasominiferaDunel in rat brain. Annals Neuroscience, 12: 67-70. (Cited by 5)
Singh, N., Patro, I.K. et al. (2004) Biochemical status of antioxidant defence enzymes in geriatric persons suffering from hypertension and ischaemic heart disease. Indian J. Cardiol., 7: 41-43.
Patro, Nisha and Patro, I.K. (2003) Effect of immuneactivator (Poly I:C) on the rat cerebral cortex. J. Tissue Res., 3(2): 71-75. (Cited by 10)
Patro, Nisha, Gupta, Praveena and Patro, I.K. (2002) Lipofuscin in cell aging and cell death. Indian J. Gerontol., 16: 45-68. (Cited by 2)
Patro, I.K., Chattopadhyay, M. and Patro, Nisha (1999) Flunarizine enhances functional recovery following sciatic nerve crush lesion in rats. Neuroscience Letters, 263: 97-100. (Impact Factor: 2.055, Cited by 55)
Patro, Nisha, Mishra, S.K., Chattopadhyay, M. and Patro, I.K. (1997) Neurotoxicological effects of deltamethrin on the postnatal development of cerebellum of rat. J. Biosci., 22: 117-130.(Impact Factor: 1.888, Cited by 29)
Patro, I.K., Patro, Nisha, Singhal, P. and Bhardwaj, S.K. (1996) Simultaneous demonstration of microscopic anatomy, Nissl, lipofuscin and cytological changes using a combination method and fluorescence technique. Acta Histochem. Cytochem., 29(3): 193-197. (Impact Factor: 1.68, Cited by 2)
Patro, I.K., Bhardwaj, S.K., Patro, Nisha and Singhal, P. (1994) Relationship between lifespan potential, specific metabolic rate and lipofuscin accumulation in neurons. J.Neurochem., 63 (Suppl. 2): 10. (Impact Factor: 4.206)
Patro, I.K., Patro, Nisha, Tiwari, B. and Singhal, P. (1994) Vascular changes in post-natal rat brain following experimental exposure to deltamethrin. J. Neurochem., 63 (Suppl. 2): 29. (Impact Factor: 4.206)
Patro, Nisha, Patro, I.K. and Mathur, R. (1993) Changes in the properties of cardiac lipofuscin with age and environmental manipulation. Asian J. Exptl. Sci., 7:57-60. (Cited by 6)
James T.J., Sharma, S.P., Gupta, S.K. and Patro, I.K. (1992) ‘Dark’ cell formation under protein malnutrition: Process of conversion and concept of ‘semi-dark’ type Purkinje cells. Indian J. Exptl. Biol., 30: 470-473. (Impact Factor: 1.295, Cited by 8)
Patro, Nisha, Patro, I.K. and Mathur, R. (1992) Age-pigments as possible markers of environmental damage; CoCl2 induced lipofuscin accumulation in myocardium. Geobios, 19: 231-234. (Cited by 5)
Patro, Nisha, Sharma, S.P. and Patro, I.K. (1992) Lipofuscin accumulation in aging myocardium and its reversal by meclophenoxate. Indian J. Med. Res. (B), 96: 192-198. (Impact Factor: 1.516, Cited by 11)
Patro, I.K. and Patro, Nisha (1992) Lipofuscin in aging brain- A selective reappraisal. Indian Rev. Life sci., 12: 133-146. (Cited by 6)
Patro, I.K., Patro, Nisha, Sharma, S.P. and James, T.J. (1991) Influence of centrophenoxine on the nucleo-cytoplasmic interaction in senile neurons. Indian J. Gerontol., 5(1): 1-11.
Patro, I.K., Sharma, S.P. and Patro, Nisha (1989) Formation and maturation of neuronal lipofuscin. Proc. Nat. Acad. Sci. (India), 59(B) III: 287-293. (Cited by 4)
Patro, I.K., Sharma, S.P., Patro, Nisha, Kataria, Asha and Upma (1988) Histopathological disruption of the cervical (spinal) central canal of white rats under restraint stress. Nat. Acad. Sci. Letters, 11(4): 127-129. (Impact Factor: 0.043)
Sharma, S.P., Patro, I.K., Patro, Nisha and James, T.J. (1988) ‘Dark’ type Purkinje cells in neuronal aging. Proc. Indian Acad. Sci. (Animal Sciences), 97: 449-453. (Cited by 2)
Patro, I.K., Sharma, S.P. and Patro, Nisha (1988) Neuronal lipofuscin: Its formation and reversibility. Indian Rev. Life Sci., 8: 95-120. (Cited by 6)
Patro, I.K., Sharma, S.P. and Patro, Nisha (1987) Influence of crowding stress on neuronal aging. Age, 10(3): 114. (Impact Factor: 5.839, Cited by 2)
Sharma, S.P., Patro, I.K. and Patro, Nisha (1987) Removal of chloroqiune induced lipofuscin by centrophenoxine. Age, 10(3): 123. (Impact Factor: 5.839, Cited by 2)
Patro, I.K., Sharma, S.P. and Patro, Nisha (1987) Pre-lipofuscin: The concept and influence of centrophenoxine. Proc. Nat. Acad. Sci. (India), 57(B) III: 105-108. (Cited by 5)
Sharma, S.P., Patro, I.K. and Goyal, Nisha (1985) Further studies on the influence of centrophenoxine on the nucleolar activity in senile rats. Age, 8(3): 82. (Impact Factor: 5.839)
Goyal, Nisha, Patro, I.K. and Sharma, S.P. (1985) Effects of centrophenoxine (ANP-235) on the extractability of cardiac lipofuscin. Age, 8(3): 97. (Impact Factor: 5.839)
Sharma, D., Sharma, S.P. and Patro, I.K. (1984) Effects of protein deficiency on the ependymal cells of the cervical spinal cord of the rat, Rattus norvegicus. J. Sci. Res., 6: 95-97.(Cited by 1)
Patro, I.K. and Sharma, S.P. (1984) Cytochemical interaction of nucleus and cytoplasm in the Purkinje cells of senile white rats under the influence of centrophenoxine. Expt. Gerontol., 19(4): 241-252. (Impact Factor: 3.342, Cited by 16)
Papers published in edited books and proceedings:
Patro, I.K. (1990) Lipofuscinolysis by four neurotropic agents: A comparative study. In Perspective in Aging Research, Eds., R. Singh and G.S. Singhal, Today and Tomorrow’s Printers and Publishers, New Delhi, pp. 133-136. (Cited by 4)
Patro, Nisha, Sharma, S.P. and Patro, I.K. (1990) Meclophenoxate and myocardial lipofuscin. In Perspective in Aging Research, Eds., R. Singh and G.S. Singhal, Today and Tomorrow’s Printers and Publishers, New Delhi, pp. 137-139.
Sharma, S.P., Gupta, S.K., James, T.J. and Patro, I.K. (1990) Influence of centrophenoxine on protein malnourishment-induced lipid peroxidation and lipofuscin in rat spinal cord. In Perspective in Aging Research, Eds., R. Singh and G.S. Singhal, Today and Tomorrow’s Printers and Publishers, New Delhi, pp.117-125.
James, T.J., Sharma, S.P., Gupta, S.K. and Patro, I.K. (1990) Aging changes in Purkinje neurons: Formation of ‘dark’ type cells. In Perspective in Aging Research, Eds., R. Singh and G.S. Singhal, Today and Tomorrow’s Printers and Publishers, New Delhi, pp. 127-132.
Sharma, S.P., James, T.J., Gupta, S.K. and Patro, I.K. (1990) Elimination of protein malnutrition-associated neuronal age-pigment by centrophenoxine. In Environmental Concern and Tissue Injury, Eds., R. Prakash and S.M. Choubey, Society for Science and Environment, Muzaffarnagar, India, pp. 123-131.
Chapters published in edited books:
Patro, Ishan, Nagayach, Aarti, Sinha, Shrstha and Patro, Nisha (2016) General Physiology and Pathophysiology of Microglia During Neuroinflammation. In Inflammation: The Common Link in Brain Pathologies, Ed. Nihar Jana, AnirbanBasu and P.N. Tandon, Springer, Singapore, pp: 17-42.
Patro, I, Saxena, K., Nagayach, A. and Patro, Nisha (2014) Involvement of glial cells in pathophysiology of peripheral nerve injury. In Contemporary Topics in Life Sciences Ed. P.P. Mathur, Narendra Publishing House, New Delhi, pp. 153-173.(Cited by 1)
Patro, Nisha, Saxena, Meghna, Kumar, K., Patro, I.K. (2011) Developmental neurotoxicology of pyrethroids: Structural and functional retardation of cerebellar development. In Emerging Trends in Zoology Eds. U.C. Srivastava and S. Kumar, Narendra Publ. House, N. Delhi, pp.1-21.(Cited by 1)
Patro, I.K. and Patro, Nisha (2009) Studies on aging of the brain. In: Neurosciences in India, Eds. Dhawan, B.N. and Seth, P.K., Indian Academy of Neurosciences and Council of Scientific and Industrial Research, New Delhi, pp.319-334.
Patro, I.K., Pathak, Seema and Patro, Nisha (2005) Central response to peripheral nerve injury: Role of non-neuronal cells. In Molecular and Cellular Neurobiology (Eds. M.K. Thakur and S. Prasad) Narosa, Delhi, pp. 217-233. (Cited by 11)
Patro, I.K., Patro, Nisha, Sharma, S.P. and Chaudhary, Asha (1991) Lipofuscinolysis: An overview. Advances in Physiological Sciences, Eds. S.K. Manchanda, W. Selvamurthy and V. Mohankumar, Macmillan (India) Co., New Delhi, pp. 441-450. (Cited by 3)
Sharma, S.P., Patro, I.K. and Goyal, Nisha (1987) Centrophenoxine: An aging-reversal agent. Aging in India: Challenge for the Society, Eds. M.L. Sharma and T.M. Dak, Ajanta Publications, Delhi, pp. 232-236.
Sharma, S.P., Patro, I.K. and Manocha, S.L. (1984) Effects of maternal dietary protein deprivation on the developing myocardium of squirrel monkeys: Lipofuscin pigment deposition and its removal. Proc. V All India Symp. Develop. Biol., pp.93-102.
Patro, I.K. and Sharma, S.P. (1982) Histochemical studies on the effect of meclophenoxatehydrocloride (Lucidril) on the neurons of senile white rats. Proc. I Conf. Assoc. Gerontol. (India), pp.80-84.